Friday Factoid Catch-Up: Your Brain on LSD

 

A Friday Factoid was written by this writer in November 2015 about the research behind psychedelic-assisted therapy. Several studies have shown that positive results can come from short courses or single sessions of psychedelic-assisted psychotherapy.

 

Until recently, there had been no modern brain images of someone on lysergic acid diethylamide (LSD) to show exactly how this drug affects the brain’s connections.
Researcher David Nutt, a neuropsychopharmacologist at Imperial College London, performed a recent two-day study with twenty healthy volunteers. On one day volunteers got a 75-microgram injection of LSD, and on the second day, they got a placebo. Researchers used three different brain imaging techniques to measure and compare blood flow, brainwaves, and functional connections within and between brain networks in volunteers on the placebo and under the influence of the drug. David Nutt stated about the discovery, “This is to neuroscience what the Higgs boson was to particle physics.” Consider that neuroscientist have waited over 50 years for these images since the drug was banned in the 1960s.

 

What researchers found sheds lights on how people who have taken psychedelics have reported feeling they are “one with nature” and that the self “dissolved.” The regions of the brain responsible for higher cognition lit up and suddenly become hyper-connected with other networks in the brain that do not normally communicate with one another. The study’s volunteers on LSD reported experiencing their sense of self dissolve, which is what researchers’ call “ego dissolution.” For people, ego dissolution can be a positive experience leading to peace, acceptance, and a new perspective of things.

 

Volunteers taking LSD appeared to process their visual world in fundamentally different ways from people who were not given the drug. Typically, the activity in our brain flows along specific neural networks. Although the primary visual cortex usually communicates mainly with other parts of the vision system, many other brain areas contributed to the processing of images in volunteers who received LSD. The visual cortex became much more active with the rest of the brain, and blood flow to visual regions also increased, which the researchers believe correlates with the hallucinations reported by volunteers and the emotional experience they can take.

 

Enzo Tagliazucchi, a neuroscientist who helped lead the study said, “This could mean that LSD results in a stronger sharing of information between regions that deal with how we perceive ourselves and how we perceive the outer world.” For example, LSD appeared to trigger the frontoparietal cortex, which is an area of the brain associated with self-consciousness, and strongly connect it with areas of the brain that process sensory information about the world outside ourselves. That interconnectedness may be creating a stronger link between our sense of self, sense of the environment, and potentially diluting the boundaries of our individuality.

 

The study found that the increased interconnectedness of brain regions, while on LSD, makes the brain of an adult resemble something like the brain of a baby, which is more free and unconstrained. In the adult brain, networks that control vision, movement, and hearing function separately. LSD lifts the barriers between these networks and stimulates the unconstrained flow of information between them that leads to a hyper-imaginative state of thinking.

 

Researchers found that communication between the parahippocampus, a brain region important in memory storage and the visual cortex, is reduced when you take LSD. When you hear music the visual cortex receives more information from the parahippocampus, and this is associated with increases in imagery with your eyes closed. Music appears to enhance the LSD experience and might be important in therapeutic settings. This could have great implications in the treatment of depression, addiction, or other mental disorders that emphasize negative thoughts. The improvement of well-being does not appear to subside after the drug has worn off.

 

References:
Brodwin, E. (2016, April 12). Mind-Blowing New Images Show How LSD Changes The Way Parts of the Brain Communicate. Business Insider. Retrieved from http://www.businessinsider.com/new-images-show-how-lsd-and-psychedelics-affect-the-brain-2016-4

 

Sample, I. (2016, April 11). LSD’s Impact On The Brain Revealed In Groundbreaking Images. The Guardian. Retreived from https://www.theguardian.com/science/2016/apr/11/lsd-impact-brain-revealed-groundbreaking-images

 

Schlanger, Z. (2016, April 12). Brain Scans Show Why LSD Makes You Feel One With Nature And Your Self Dissolve. News Week. Retrieved from http://www.newsweek.com/2016/04/22/lsd-brain-scan-nature-self-psychedelics-446513.html

 

Jonathan Torres, M.S.
WKPIC Pre-Doctoral Intern

 

 

Friday Factoids: Post-Partum Psychosis


 

It is safe to say that a good majority of the population has heard of postpartum depression.  Many may even know a new mother who has experienced this condition.  However, far fewer have heard of or truly understand postpartum psychosis, this writer included. 

 

Postpartum psychosis, also referred to as postnatal psychosis, is very rare. It develops in only 0.1% of all women after they give birth. Women who have experienced the condition previously are said to have a much higher rate of 30% with each additional pregnancy. Those who already have a serious mental illness, such as bipolar disorder or schizophrenia, are also at an increased risk.

 

Postpartum psychosis can present with a rapid onset of a few days to that of a few weeks following child birth.  A limited number of women do not exhibit symptoms, however, until they cease breast feeding, or until their menstrual cycles resume.  Most all cases develop within two weeks, though. It is important to note that it is a medical emergency and should be treated immediately to help reduce the severity of symptoms.

 

The most common symptoms of postpartum psychosis include hallucinations and delusions. Secondary symptoms may vary. They can include paranoia, mania, loss of inhibitions, low mood, agitation, restlessness, anxiety, trouble sleeping, loss of appetite and/or severe confusion. Rapidly fluctuating moods can also occur. A minimal percentage of women effected by this condition may even experience mania and depression simultaneously.

 

Due to the presentation of symptomatology, the psychiatric condition may be a severe emergency that requires admission to hospital for treatment.  When at all possible, it is best for the patient to be admitted with her newborn, into special psychiatric care options referred to as a mother-and-baby units. This helps to facilitate the continued bonding of mother and baby.  Medication management figures largely included in symptom reduction. The medications chosen often consist of a blend of neuroleptic (s), antidepressant(s) and mood stabilizers. Most women who follow medical protocol make a full recovery within several months.

 

Work Cited
K. K. (2013, October 6). Postpartum Psychosis: What You Might Not Know. Retrieved March 14, 2016, from https://www.psychologytoday.com/blog/isnt-what-i-expected/201310/postpartum-psychosis-what-you-might-not-know 

 

Sit, D., ROTHSCHILD, A. J., & WISNER, K. L. (2011, June 7). A Review of Postpartum Psychosis. Retrieved  March 14, 2016, from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109493/ doi: 10.1089/jwh.2006.15.352

 

Crystal K. Bray,
WKPIC Doctoral Intern

 

 

Article Review: Obstacles to Care in First-Episode Psychosis Patients With a Long Duration of Untreated Psychosis

 

In the field of mental health, both clinical and research efforts have focused on the importance of early detection and intervention in psychosis. Research has shown that this strategy might lead to an increased chance of preventing, delaying the onset of, or reducing problems resulting from psychosis. In addition, treatment delays may add to the burden experienced by the individuals and their family, and may have social, educational and occupational consequences.

 

Reluctance to accept a stigma-laden diagnosis and fear of mental health services may delay help seeking. Families, friends or the individual’s broader social network might be the first to recognize pathological changesbut may lack the ability to correctly identify these changes as symptoms of psychosis. The aim of this study was to gain knowledge about factors that prevent or delay patients with a long duration of psychosis from accessing psychiatric healthcare services at an earlier stage and their personal views on the impact of ongoing informational campaigns on help-seeking behavior.

 

In this study, eight patients who experienced duration of untreated psychosis lasing for more than six months were interviewed. Participants included four men and four women who were both students and full-time employees, with age ranging from 17 to 44 years. The patients must meet the DSM-IV-TR criteria for first-episode schizophrenia, schizophreniform disorder, schizoaffective disorder, brief psychotic episode, delusional disorder, drug-induced psychosis, affective psychosis with mood incongruent delusions, or psychotic disorder not otherwise specified. The interview format focused on the following main topics: symptom awareness, help-seeking behavior, family and professional involvement, awareness and feedback. Each topic was introduced with an open-ended question and follow-up questions were asked depending on how much the patient elaborated. The interviews were conducted by the first author and lasted 40 minutes on average.

 

Based on the results, the authors identified five main themes, which include: failure to recognize symptoms of psychosis, difficulties expressing their experiences, concerns about stigma, poor psychosis detection skills among healthcare professionals, and lack of awareness or understanding of available community resources. The five themes identified suggest participants were unable to recognize or understand the severity of their symptoms. Further, although family members or others sometimes recognized the initial symptoms of psychosis development, these symptoms were attributed to reasons other than psychosis. Participants reported that healthcare professionals also had trouble identifying emerging signs of psychosis. Lastly, information about available resources needs to be carefully tailored to relay information to people who do not consider themselves as currently experiencing signs of psychosis.

 

The majority of participants reported they failed to understand that they needed help at the time of the onset of their psychosis. Instead, they believed or hoped the symptoms and changes they experienced would eventually pass without intervention. Many participants reported that family and friends were the first to notice changes in mood and behavior. Family or friends attributed these changes to difficulty concentrating, “teenage behavior,” or introverted personality rather than the development of a psychiatric illness. In cases where family members suspected the presence of a psychiatric illness, depression was suspected rather than psychosis. Half of the participants reported having no knowledge about psychosis at the time of onset and attributed their symptoms to depression or an anxiety disorder.

 

An additional obstacle to seeking treatment was uncertainty about how to ask for help. Many participants had trouble explaining their symptoms to healthcare professionals. When they first entered psychiatric treatment, healthcare professionals initially misinterpreted symptoms as depression or anxiety. One participant reported that although she knew where to go to seek help, she did not know how to express herself. Another reason for not seeking help involved concerns that family and others might consequently find out about the mental illness. Many of the participants reported that they deliberately hid their symptoms due to concerns about the reaction of others.

 

More than half of the participants reported that healthcare professionals had failed to recognize their symptoms as related to psychosis. One of the participants raised concerns about his symptoms with his general practitioner (GP) on several occasions over a period of 1 year before they were correctly identified. Some participants had sought help repeatedly from their GPs or the school nurse during periods when they experienced troubling symptoms. At times, they received treatment from GPs, psychologists, psychiatrists and school nurses for symptoms of anxiety and depression, but healthcare professionals failed to correctly detect and diagnose psychosis. One participant had described the presence of auditory hallucinations upon admission to an adolescent outpatient clinic. Still, he was not offered assessment for psychosis.

 

The majority of participants said they had seen mental health treatment ads in newspapers or as posters at school. The majority of participants who had seen the ads, however, did not seek help despite awareness of the programs. One participant mentioned that the ads failed to help him understand the true nature or experience of psychosis. Others did not consider themselves as belonging to the target group mainly due to feeling ‘not sick enough.’ The only participant who did seek help reported that he eventually made contact many years after seeing treatment ads.

 

At first, he did not think he belonged to the target group. As his condition worsened and he experienced all the symptoms mentioned in one of the ads. One participant believed she was actually too sick to get help and felt treatment was not worthwhile. Participants also stated they did not want to unnecessarily bother mental health staff. Others were worried that making contact might lead to a hospital admission.

 

Although this study utilized a small sample size, it nevertheless represents many of the fears individuals with first-episode psychosis experience. In our communities emphasis should be placed on having more information and education readily available at schools for students and parents. Students, teachers and school nurses should receive information sessions from mental health professionals about signs and symptoms and how to refer students to available treatments. Additionally, information about mental health should start at an earlier point, for example, in junior high school. National newspapers, journal articles, and the Internet may be beneficial channels for communication of available resources in the community.

 

References:
Bay, N.; Bjornestad, J.; Johannessen, J. O., Larsen, T. K., & Joa, I. (2016). Obstacles to care in first-episode psychosis patients with a long duration of untreated psychosis. Early Intervention in Psychiatry, 10, 71-76.

 

Jonathan Torres, M.S.
WKPIC Doctoral Intern

 

 

Friday Factoids: Schizophrenia and Premature Death

Schizophrenia has long been one of mental health’s most studied disorders. Our knowledge base regarding the diagnosis has grown by leaps and bounds over many years of research. Most people are aware of the cognitive, negative and psychotic symptoms associated with schizophrenia. However, far fewer realize that premature death can also be a distinctive feature of the disorder.

 

Statistically speaking, adults who have schizophrenia are typically expected to live only 70% of a normal lifespan when compared to same age peers. Essentially this means they will live 15-25 years less than the average person.  Striking as it may be to some, this is information that we have known for some time. However, researchers have recently updated this data to include all age groups and demographics.

 

Researcher Mark Olfson and his team recently studied a group of one million people with schizophrenia. During their study period, 74,000 individuals passed away. Of those 74,000, Dr. Olfson and team were able to identify the cause of death for 65,500 of them. They then compared the identified cause and age with that of same age peers. Their findings indicated that the increased rate of premature death crossed all age ranges as well as demographics, leaving no one group/age immune.

 

The data revealed that unnatural as well as natural causes of death were both increased by more than three times when compared to normative mortality rates of the same nature.  Natural causes of death by far accounted for the majority of causes. Lung cancer, other cancers, cardiovascular disease, influenza, and diabetes accounted for most of the natural causes. Suicide and accidental deaths were deemed to be the majority of unnatural causes.

 

Crystal Bray
WKPIC Doctoral Intern

 

Article Review: Nancy McWilliams, Psychoanalytic Diagnosis. Chapter 3: Developmental Levels of Personality Organization

 

Psychologists work with complex diagnostic and treatment issues on a daily basis. Current standards of care (and reimbursement) have guided diagnosis and treatment to seem focused on DSM-5 categories and ICD-10 codes. Clinicians I have interacted with seem to appreciate the aspects of continuum versus strictly categorical diagnoses added to DSM-5. This may open avenues into helping psychologists better describe, understand and treat their patients with compassion.

 

A continuum model of personality organization is outlined in chapter 3 of Nancy McWillam’s book, Psychoanalytic Diagnosis. This model has important implications in the work clinicians do with patients regardless of their chosen theoretical orientation. The psychodynamic concepts in this particular chapter apply to any overriding theoretical orientation just as the concept of transference does. In the middle of the 20th century and beyond, many analysts followed in the tradition of Freud in differentiating psychopathological conditions as either neurotic or psychotic. Neurotics were described as having some insight into their difficulties of which, a source of reality based stress was likely being managed poorly. Conversely, psychotics who were having psychological difficulties experienced distress based on misinterpretations of reality. At the same time other clinicians began to question these discrete categories because they noticed patients who seemed to fall on a borderline between neurosis and psychosis. It is a crucial point to understand that this concept is NOT describing Borderline Personality Disorder. We all have a unique personality that has developed for a variety of biological and psychological reasons. The model described in McWilliams’s book and by many other modern psychodynamic theorists, organizes personality in a thermometer like fashion with three overall categories: Neurotic, Borderline and Psychotic. Levels of personality organization tend to lend themselves to the idea of fixation in a particular developmental stage.

 

Neurotic Personality Organization
When a patient with Neurotic Personality Organization (NPO) presents to psychotherapy, it is more likely that they see their distress as ego dystonic or ego alien. NPO typically relies on repression as a defense mechanism as opposed to more primitive defenses such as splitting, or projective identification. If you ask a neurotically organized patient to tell you about themselves, they can describe a person who has an integrated sense of identity on some level. They can tell you enduring traits about themselves and have some insight into what parts of themselves have been more constant over time. It requires a severe biological or traumatic event for Neurotically Organized personalities to lose touch with reality. Schizophrenia as well as any Axis I disorder can exist in a neurotically organized individual. Neurotically organized individuals with psychotic disorders will be able to identify psychotic symptoms as not reality based and quickly access mental health services as a result. They tend to be individuals who will demonstrate a stronger recovery from psychosis due to remaining on prescribed medications, being able to identify stressful triggers, and most important reality testing remains intact even when the individual begins to experience symptoms. The patient knows they are sick and seeks help long before psychiatric hospitalization occurs.

 

Borderline Personality Organization
Borderline Personality Organization (again I cannot stress enough this is NOT the personality disorder), relies on a less developed defensive repertoire. Splitting occurs frequently at this general borderline personality organization (BPO) as well as with borderline personality disorders. Black and white thinking can be a part of those organized at this level. There are only good and bad, “my” way or the wrong way. If a BPO is asked to describe who they are the description may seem to vacillate based on the situation they are in. Their own sense of identity is not formed so it is more likely to be shaped as a result of the current relationship or environmental situation. Those with BPO are more prone to “micropsychotic” dips in times of stress. One diagnostic consideration this can be particularly helpful with is major depression. A depressed NPO will likely be able to identify stressors and respond to psychotherapy and medication in an expected manner. A depressed BPO is likely to have psychotic features. The patient is less likely to be able to explain what preceded the depression and much less likely to identify any time in their life they were not depressed. They are more likely to see any pathology as ego syntonic and be brought in for treatment by family members or others. Depressed BPO patients have great difficulty identifying a gray area between depressed and non-depressed states. They may describe themselves as “bipolar” when the actual problem is their inability to identify and label affect. Patients who report they have been diagnosed as bipolar but do not respond to “any” medications should raise some suspicion for this particular organizational level. BPO is unstable and ever changing which can give the impression of a bipolar element. Those functioning at this level may have times of calmer more successful neurotic level functioning coupled with dips into psychotic level function.

 

Psychotic Personality Organization
Like the other organizational levels this is not a psychotic “disorder.” Psychotically Organized Personalities are less likely to respond to standard treatment and more difficult to build rapport with. They often will not know how to begin describing themselves or any personality traits they have. Psychotic level individuals have lacking insight into their difficulties. If they have a psychotic disorder they may even seem at times to be unaware of it. They are not distressed by what others from the outside may conceptualize as distress. It is rare for this personality organization to be able to assess reality. This is the patient that may seem to make one bad decision after another based on a fact pattern others cannot identify. Psychotically organized patients are more likely to use schizoid retreat as a defense. They isolate from others and engage in an internal fantasy world that becomes difficult for them to differentiate from reality. This inevitable leads to interpersonal difficulties and more frequent interaction with law enforcement. A depressed psychotically organized patient is more likely to act out violently and see this as a viable solution to their discomfort. This patient will be disorganized and unable to identify why they are depressed or if they ever have been before. Some have learned to state they “always” have been depressed in some effort at interacting with treating clinicians. Further evaluation may identify few things that make sense in the patient’s behavior. It is important to gain an understanding of what it is that this individual (not the clinician) describes as reality and start working from that point.

 

Understanding
When treating patients many clinicians identify that not all depressed patients are alike. Why it is some seem to have insight and respond to treatment while others seem much more difficult? Identifying a patient’s personality organization can help clinicians in a variety of ways. It is less difficult to understand why a psychotically organized depressed patient will need a longer length of treatment and repeated treatment exposures. Understanding the personality context of a disorder may help decrease the clinician’s frustrations when treatment seems more difficult. The patient can be saved some degree of distress when they are aware of what their treatment may look like. The patient who is at a psychotic level of organization will need treatment patiently described over and over to understand the realities of treatment. Lapses in treatment make more sense when the clinician understands that they may be a result of the patient’s organizational level.

 

Reference
McWilliams, N. (1994) Psychoanalytic Diagnosis. Guilford Press, New York, NY.

 

Rain Blohm, MS
WKPIC Doctoral Intern