Friday Factoids: Post-Partum Psychosis


 

It is safe to say that a good majority of the population has heard of postpartum depression.  Many may even know a new mother who has experienced this condition.  However, far fewer have heard of or truly understand postpartum psychosis, this writer included. 

 

Postpartum psychosis, also referred to as postnatal psychosis, is very rare. It develops in only 0.1% of all women after they give birth. Women who have experienced the condition previously are said to have a much higher rate of 30% with each additional pregnancy. Those who already have a serious mental illness, such as bipolar disorder or schizophrenia, are also at an increased risk.

 

Postpartum psychosis can present with a rapid onset of a few days to that of a few weeks following child birth.  A limited number of women do not exhibit symptoms, however, until they cease breast feeding, or until their menstrual cycles resume.  Most all cases develop within two weeks, though. It is important to note that it is a medical emergency and should be treated immediately to help reduce the severity of symptoms.

 

The most common symptoms of postpartum psychosis include hallucinations and delusions. Secondary symptoms may vary. They can include paranoia, mania, loss of inhibitions, low mood, agitation, restlessness, anxiety, trouble sleeping, loss of appetite and/or severe confusion. Rapidly fluctuating moods can also occur. A minimal percentage of women effected by this condition may even experience mania and depression simultaneously.

 

Due to the presentation of symptomatology, the psychiatric condition may be a severe emergency that requires admission to hospital for treatment.  When at all possible, it is best for the patient to be admitted with her newborn, into special psychiatric care options referred to as a mother-and-baby units. This helps to facilitate the continued bonding of mother and baby.  Medication management figures largely included in symptom reduction. The medications chosen often consist of a blend of neuroleptic (s), antidepressant(s) and mood stabilizers. Most women who follow medical protocol make a full recovery within several months.

 

Work Cited
K. K. (2013, October 6). Postpartum Psychosis: What You Might Not Know. Retrieved March 14, 2016, from https://www.psychologytoday.com/blog/isnt-what-i-expected/201310/postpartum-psychosis-what-you-might-not-know 

 

Sit, D., ROTHSCHILD, A. J., & WISNER, K. L. (2011, June 7). A Review of Postpartum Psychosis. Retrieved  March 14, 2016, from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3109493/ doi: 10.1089/jwh.2006.15.352

 

Crystal K. Bray,
WKPIC Doctoral Intern

 

 

Posted in Blog, Continuing Education, Current Interns, Friday Factoids, Mental Health and Wellness, Resources for Interns | Tagged , , | Leave a comment

Article Review: Obstacles to Care in First-Episode Psychosis Patients With a Long Duration of Untreated Psychosis

 

In the field of mental health, both clinical and research efforts have focused on the importance of early detection and intervention in psychosis. Research has shown that this strategy might lead to an increased chance of preventing, delaying the onset of, or reducing problems resulting from psychosis. In addition, treatment delays may add to the burden experienced by the individuals and their family, and may have social, educational and occupational consequences.

 

Reluctance to accept a stigma-laden diagnosis and fear of mental health services may delay help seeking. Families, friends or the individual’s broader social network might be the first to recognize pathological changesbut may lack the ability to correctly identify these changes as symptoms of psychosis. The aim of this study was to gain knowledge about factors that prevent or delay patients with a long duration of psychosis from accessing psychiatric healthcare services at an earlier stage and their personal views on the impact of ongoing informational campaigns on help-seeking behavior.

 

In this study, eight patients who experienced duration of untreated psychosis lasing for more than six months were interviewed. Participants included four men and four women who were both students and full-time employees, with age ranging from 17 to 44 years. The patients must meet the DSM-IV-TR criteria for first-episode schizophrenia, schizophreniform disorder, schizoaffective disorder, brief psychotic episode, delusional disorder, drug-induced psychosis, affective psychosis with mood incongruent delusions, or psychotic disorder not otherwise specified. The interview format focused on the following main topics: symptom awareness, help-seeking behavior, family and professional involvement, awareness and feedback. Each topic was introduced with an open-ended question and follow-up questions were asked depending on how much the patient elaborated. The interviews were conducted by the first author and lasted 40 minutes on average.

 

Based on the results, the authors identified five main themes, which include: failure to recognize symptoms of psychosis, difficulties expressing their experiences, concerns about stigma, poor psychosis detection skills among healthcare professionals, and lack of awareness or understanding of available community resources. The five themes identified suggest participants were unable to recognize or understand the severity of their symptoms. Further, although family members or others sometimes recognized the initial symptoms of psychosis development, these symptoms were attributed to reasons other than psychosis. Participants reported that healthcare professionals also had trouble identifying emerging signs of psychosis. Lastly, information about available resources needs to be carefully tailored to relay information to people who do not consider themselves as currently experiencing signs of psychosis.

 

The majority of participants reported they failed to understand that they needed help at the time of the onset of their psychosis. Instead, they believed or hoped the symptoms and changes they experienced would eventually pass without intervention. Many participants reported that family and friends were the first to notice changes in mood and behavior. Family or friends attributed these changes to difficulty concentrating, “teenage behavior,” or introverted personality rather than the development of a psychiatric illness. In cases where family members suspected the presence of a psychiatric illness, depression was suspected rather than psychosis. Half of the participants reported having no knowledge about psychosis at the time of onset and attributed their symptoms to depression or an anxiety disorder.

 

An additional obstacle to seeking treatment was uncertainty about how to ask for help. Many participants had trouble explaining their symptoms to healthcare professionals. When they first entered psychiatric treatment, healthcare professionals initially misinterpreted symptoms as depression or anxiety. One participant reported that although she knew where to go to seek help, she did not know how to express herself. Another reason for not seeking help involved concerns that family and others might consequently find out about the mental illness. Many of the participants reported that they deliberately hid their symptoms due to concerns about the reaction of others.

 

More than half of the participants reported that healthcare professionals had failed to recognize their symptoms as related to psychosis. One of the participants raised concerns about his symptoms with his general practitioner (GP) on several occasions over a period of 1 year before they were correctly identified. Some participants had sought help repeatedly from their GPs or the school nurse during periods when they experienced troubling symptoms. At times, they received treatment from GPs, psychologists, psychiatrists and school nurses for symptoms of anxiety and depression, but healthcare professionals failed to correctly detect and diagnose psychosis. One participant had described the presence of auditory hallucinations upon admission to an adolescent outpatient clinic. Still, he was not offered assessment for psychosis.

 

The majority of participants said they had seen mental health treatment ads in newspapers or as posters at school. The majority of participants who had seen the ads, however, did not seek help despite awareness of the programs. One participant mentioned that the ads failed to help him understand the true nature or experience of psychosis. Others did not consider themselves as belonging to the target group mainly due to feeling ‘not sick enough.’ The only participant who did seek help reported that he eventually made contact many years after seeing treatment ads.

 

At first, he did not think he belonged to the target group. As his condition worsened and he experienced all the symptoms mentioned in one of the ads. One participant believed she was actually too sick to get help and felt treatment was not worthwhile. Participants also stated they did not want to unnecessarily bother mental health staff. Others were worried that making contact might lead to a hospital admission.

 

Although this study utilized a small sample size, it nevertheless represents many of the fears individuals with first-episode psychosis experience. In our communities emphasis should be placed on having more information and education readily available at schools for students and parents. Students, teachers and school nurses should receive information sessions from mental health professionals about signs and symptoms and how to refer students to available treatments. Additionally, information about mental health should start at an earlier point, for example, in junior high school. National newspapers, journal articles, and the Internet may be beneficial channels for communication of available resources in the community.

 

References:
Bay, N.; Bjornestad, J.; Johannessen, J. O., Larsen, T. K., & Joa, I. (2016). Obstacles to care in first-episode psychosis patients with a long duration of untreated psychosis. Early Intervention in Psychiatry, 10, 71-76.

 

Jonathan Torres, M.S.
WKPIC Doctoral Intern

 

 

Posted in Blog, Continuing Education, Current Interns, Mental Health and Wellness, Resources for Interns | Tagged , , | Leave a comment

Our Soon-To-Be STARS

Letting you know a few fun facts about WKPIC’s incoming class of 2016-2017!

 

Screen Shot 2015-12-08 at 8.19.29 PMDannie Harris recently discovered unknown talents in both acting and singing delirious children’s songs while making a professional training video. She’s quite proficient at Row-Row-Row-Your-Boat–and we think her proper classification is mezzo-soprano?

 

 

 

 

 

 

Jennifer Roman tells us she also answers to Jenny or Jenn. Her favorite color is green, butJennifer Roman she generally says it’s blue–but she didn’t tell us why! We will be very interested in pursuing this mystery when she gets here. Also, I’m fairly certain the nefarious Dr. Greene, group supervision aficionado and resident prankster, may be busy devising a personality test based on this color-hiding-confusion revelation.

 

 

 

 

 

Dianne Rapsey-VanBuren
Dianne Rapsey-Vanburen generously offered up 10 Fun Facts about herself. Here they are, in her own words:

1) I only support two sports teams, the New York Yankees – and whoever beats the Red Sox. (Clearly, Dr. Greene will need to attempt sports education for this one, along with all the rabid UK fans at this internship site). 

2) I now consider myself an extremely adventurous and thrill seeking individual, since last week I took my toddler son inside a pier 1 department store. 

3) Although I am obsessed with watching cooking shows, I believe the only reason I have a kitchen is because it came with the house.

4) Among many “non-drunk” stories, I once had my socks stolen off my feet on a New York City Subway.

5) I have never read any of the books, or, seen a single episode of Harry Potter.

6) I cry every time I watch the movie “the color purple”.

7) Once sat court side at a Knicks game, in Woody Allen season box seats( again no-alcohol involved)

8) On my I-pod I have complete collections of lil Wayne and Jimmy Buffet.

9) I love peonies, but hate phonies.

10) Started my own ‘religious’ fight club in high school.

 

 

We are looking forward to working with these brilliant, funny ladies–singing, green-blue confusion, missing socks, and all!

 

Susan R. Redmond-Vaught, Ph.D.
Director, WKPIC

 

 

Posted in Blog, Dr. Vaught, Social | 4 Comments

Friday Factoids: Have Your Chocolate, and Eat It, Too!

 

Many of us have long been waiting for a justifiable reason to indulge in chocolate that did not first involve having a migraine. It is with great excitement that this writer must announce that our day is coming nearer. A fairly recent trial found that older adults who have a high dietary intake of flavanols, like those found in cocoa, have heightened memory performance on object-recognition tasks. Additionally, it also increased neural activity in the dentate gyrus of our hippocampi as measured by a fMRI.

 

Brickman et al. tracked 38 individuals over a period of 12 weeks. During that time, half of the sample population received a high intake diet of flavanols and the remaining sample followed the low intake diet. The team found that those receiving high intakes of flavanols had measurably improved neural activity, increased blood flow in the dentate gyrus and increased memory functioning on object recognition tasks. They noted that the increased blood flow was a direct correlation to improvement in memory functioning but needed to go a step further to prove this theory.

 

In addition to a massive amount of data collection, the team created a digital test called the ModBent. They designed the ModBent to be an extremely difficult memory recognition task that activated the dentate gyrus. It was designed to activate this region of the brain without triggering other areas known to be specific to memory. To establish the validity of the ModBent, Brickman et al. organized a double-dissociation study using the tool in healthy adults. The study confirmed that the measure did in fact only activate the dentate gyrus but that it also was receptive to the age of the examinee. The group used this information and designed two different versions of the ModBent. They administered one test at the beginning of their study and one at the end. Having two versions of the assessment prevented the participants from potentially experiencing repeat assessment practice effects.

 

The study found that high-flavanol group’s performance was on average 630 ms higher than the low-flavanol group. They compared the difference in performance to knock-out mice studies measuring for memory loss. It was noted that such a difference paralleled the results of aging in the brain by approximately three decades. This correlation was extremely significant to their findings. Brickman et al. established clear evidence that including flavanols in one’s diet would be beneficial to degree in reversing cognitive decline in memory.

 

Work Cited
Brickman, Adam M., Khan, Usman A., Provenzano, Frank A., Yeung, Lok-Kin, Suzuki, Wendy, Schroeter, Hagen, Wall, Melanie, Sloan, Richard P., & Small, Scott A.  Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults. Nature Neuroscience. 12, 1978-1806 (2014).

 

It should be noted that Brickman et al. hypothesized that combining a high-flavanol diet with the added benefits of exercise (peak oxygen levels in our blood) would produce even greater results on the ModBent. However, in collecting data and measures for the comparison, they found that there was no difference in the aerobic group versus non-exercise group when measuring for peak oxygen intake. Therefore, they did not move forward with the study and the effects of a high-flavanol diet combined with exercise are still currently unknown.

 

Crystal Bray
WKPIC Doctoral Intern

Posted in Blog, Continuing Education, Current Interns, Friday Factoids, Mental Health and Wellness | Tagged , , | 2 Comments

Friday Factoids: Schizophrenia and Premature Death

Schizophrenia has long been one of mental health’s most studied disorders. Our knowledge base regarding the diagnosis has grown by leaps and bounds over many years of research. Most people are aware of the cognitive, negative and psychotic symptoms associated with schizophrenia. However, far fewer realize that premature death can also be a distinctive feature of the disorder.

 

Statistically speaking, adults who have schizophrenia are typically expected to live only 70% of a normal lifespan when compared to same age peers. Essentially this means they will live 15-25 years less than the average person.  Striking as it may be to some, this is information that we have known for some time. However, researchers have recently updated this data to include all age groups and demographics.

 

Researcher Mark Olfson and his team recently studied a group of one million people with schizophrenia. During their study period, 74,000 individuals passed away. Of those 74,000, Dr. Olfson and team were able to identify the cause of death for 65,500 of them. They then compared the identified cause and age with that of same age peers. Their findings indicated that the increased rate of premature death crossed all age ranges as well as demographics, leaving no one group/age immune.

 

The data revealed that unnatural as well as natural causes of death were both increased by more than three times when compared to normative mortality rates of the same nature.  Natural causes of death by far accounted for the majority of causes. Lung cancer, other cancers, cardiovascular disease, influenza, and diabetes accounted for most of the natural causes. Suicide and accidental deaths were deemed to be the majority of unnatural causes.

 

Crystal Bray
WKPIC Doctoral Intern

 

Posted in Blog, Continuing Education, Current Interns, Friday Factoids, Mental Health and Wellness, Resources for Interns | Tagged , , | Leave a comment

Congratulations, Leadership 2015-2016 Graduates!

 

Hooray for all of you, Pennyroyal and WSH Leadership Forum graduates!

 

 

Dr. Greene and I were very happy to have all of you in class. Go forth now, and do many great things.

 

100_8224100_8225100_8227

 

Dr. Redmond-Vaught

 

 

 

Posted in Blog, Social | Leave a comment

Article Review: Nancy McWilliams, Psychoanalytic Diagnosis. Chapter 3: Developmental Levels of Personality Organization

 

Psychologists work with complex diagnostic and treatment issues on a daily basis. Current standards of care (and reimbursement) have guided diagnosis and treatment to seem focused on DSM-5 categories and ICD-10 codes. Clinicians I have interacted with seem to appreciate the aspects of continuum versus strictly categorical diagnoses added to DSM-5. This may open avenues into helping psychologists better describe, understand and treat their patients with compassion.

 

A continuum model of personality organization is outlined in chapter 3 of Nancy McWillam’s book, Psychoanalytic Diagnosis. This model has important implications in the work clinicians do with patients regardless of their chosen theoretical orientation. The psychodynamic concepts in this particular chapter apply to any overriding theoretical orientation just as the concept of transference does. In the middle of the 20th century and beyond, many analysts followed in the tradition of Freud in differentiating psychopathological conditions as either neurotic or psychotic. Neurotics were described as having some insight into their difficulties of which, a source of reality based stress was likely being managed poorly. Conversely, psychotics who were having psychological difficulties experienced distress based on misinterpretations of reality. At the same time other clinicians began to question these discrete categories because they noticed patients who seemed to fall on a borderline between neurosis and psychosis. It is a crucial point to understand that this concept is NOT describing Borderline Personality Disorder. We all have a unique personality that has developed for a variety of biological and psychological reasons. The model described in McWilliams’s book and by many other modern psychodynamic theorists, organizes personality in a thermometer like fashion with three overall categories: Neurotic, Borderline and Psychotic. Levels of personality organization tend to lend themselves to the idea of fixation in a particular developmental stage.

 

Neurotic Personality Organization
When a patient with Neurotic Personality Organization (NPO) presents to psychotherapy, it is more likely that they see their distress as ego dystonic or ego alien. NPO typically relies on repression as a defense mechanism as opposed to more primitive defenses such as splitting, or projective identification. If you ask a neurotically organized patient to tell you about themselves, they can describe a person who has an integrated sense of identity on some level. They can tell you enduring traits about themselves and have some insight into what parts of themselves have been more constant over time. It requires a severe biological or traumatic event for Neurotically Organized personalities to lose touch with reality. Schizophrenia as well as any Axis I disorder can exist in a neurotically organized individual. Neurotically organized individuals with psychotic disorders will be able to identify psychotic symptoms as not reality based and quickly access mental health services as a result. They tend to be individuals who will demonstrate a stronger recovery from psychosis due to remaining on prescribed medications, being able to identify stressful triggers, and most important reality testing remains intact even when the individual begins to experience symptoms. The patient knows they are sick and seeks help long before psychiatric hospitalization occurs.

 

Borderline Personality Organization
Borderline Personality Organization (again I cannot stress enough this is NOT the personality disorder), relies on a less developed defensive repertoire. Splitting occurs frequently at this general borderline personality organization (BPO) as well as with borderline personality disorders. Black and white thinking can be a part of those organized at this level. There are only good and bad, “my” way or the wrong way. If a BPO is asked to describe who they are the description may seem to vacillate based on the situation they are in. Their own sense of identity is not formed so it is more likely to be shaped as a result of the current relationship or environmental situation. Those with BPO are more prone to “micropsychotic” dips in times of stress. One diagnostic consideration this can be particularly helpful with is major depression. A depressed NPO will likely be able to identify stressors and respond to psychotherapy and medication in an expected manner. A depressed BPO is likely to have psychotic features. The patient is less likely to be able to explain what preceded the depression and much less likely to identify any time in their life they were not depressed. They are more likely to see any pathology as ego syntonic and be brought in for treatment by family members or others. Depressed BPO patients have great difficulty identifying a gray area between depressed and non-depressed states. They may describe themselves as “bipolar” when the actual problem is their inability to identify and label affect. Patients who report they have been diagnosed as bipolar but do not respond to “any” medications should raise some suspicion for this particular organizational level. BPO is unstable and ever changing which can give the impression of a bipolar element. Those functioning at this level may have times of calmer more successful neurotic level functioning coupled with dips into psychotic level function.

 

Psychotic Personality Organization
Like the other organizational levels this is not a psychotic “disorder.” Psychotically Organized Personalities are less likely to respond to standard treatment and more difficult to build rapport with. They often will not know how to begin describing themselves or any personality traits they have. Psychotic level individuals have lacking insight into their difficulties. If they have a psychotic disorder they may even seem at times to be unaware of it. They are not distressed by what others from the outside may conceptualize as distress. It is rare for this personality organization to be able to assess reality. This is the patient that may seem to make one bad decision after another based on a fact pattern others cannot identify. Psychotically organized patients are more likely to use schizoid retreat as a defense. They isolate from others and engage in an internal fantasy world that becomes difficult for them to differentiate from reality. This inevitable leads to interpersonal difficulties and more frequent interaction with law enforcement. A depressed psychotically organized patient is more likely to act out violently and see this as a viable solution to their discomfort. This patient will be disorganized and unable to identify why they are depressed or if they ever have been before. Some have learned to state they “always” have been depressed in some effort at interacting with treating clinicians. Further evaluation may identify few things that make sense in the patient’s behavior. It is important to gain an understanding of what it is that this individual (not the clinician) describes as reality and start working from that point.

 

Understanding
When treating patients many clinicians identify that not all depressed patients are alike. Why it is some seem to have insight and respond to treatment while others seem much more difficult? Identifying a patient’s personality organization can help clinicians in a variety of ways. It is less difficult to understand why a psychotically organized depressed patient will need a longer length of treatment and repeated treatment exposures. Understanding the personality context of a disorder may help decrease the clinician’s frustrations when treatment seems more difficult. The patient can be saved some degree of distress when they are aware of what their treatment may look like. The patient who is at a psychotic level of organization will need treatment patiently described over and over to understand the realities of treatment. Lapses in treatment make more sense when the clinician understands that they may be a result of the patient’s organizational level.

 

Reference
McWilliams, N. (1994) Psychoanalytic Diagnosis. Guilford Press, New York, NY.

 

Rain Blohm, MS
WKPIC Doctoral Intern

 

Posted in Blog, Continuing Education, Current Interns, Mental Health and Wellness, Resources for Interns | Tagged , , , , , , | Leave a comment

Friday Factoids: Where Do the 2016 Presidential Candidates Stand on Mental Health Issues?

 

In an election often dominated by worries about the economy and national security, mental health gets comparatively little exposure as a serious issue on the presidential campaign trail. In fact, during my search for information it was difficult to find clear and concise information about the candidates’ stance on mental health issues in America. During this election season, the issue of mental health services has been brought up most frequently when candidates have discussed mass shootings. Candidates on both sides of the aisle have stressed the need to prevent mentally ill people from acquiring guns. Democrats have advocated for gun control and Republicans argued that the lack of treatment for mental health issues should be blamed for mass shootings rather than the gun industry.

 

The heroin epidemic has provided an opportunity for candidates to link drug addiction and mental health, with candidates like Bernie Sanders arguing that the nation’s prison system must stop being used as a substitute for treatment. In addition, mental health is also commonly mentioned in regards to the Department of Veterans Affairs, with many candidates promising to reform the agency and give veterans access to proper mental health care. It is even rarer for candidates to mention mental health as its own issue, one that is not prompted by a national crisis or by a question from an audience member.

 

Out of all the 2016 candidates, Hillary Clinton and John Kasich are perhaps the most vocal advocates for mental health care. Clinton has called for mental health to be treated with parity to physical health issues. During the run-up to the Iowa caucus, Clinton frequently criticized the state’s Republican governor, Terry Branstad, for closing two of the state’s four mental hospitals. Kasich, who is often attacked by conservatives for expanding Medicaid in his home state of Ohio, has argued that the move helped treat the mentally ill. Bernie Sanders occasionally speaks about mental health as a part of his health care plan, and has called for a “mental health revolution,” usually in regards to making sure people are treated in light of the national conversation on mental health and guns.

 

Marco Rubio has talked about the stigma surrounding mental health issues when asked about it by voters. Some candidates have taken a different approach and have joked about the issue. Ted Cruz has said multiple times that he has “a lot of experience with mental health” issues because he’s dealt with Congress. One day after a man shot two journalists on live television Donald Trump said he is opposed to tightening gun laws in the U.S. but is in favor of addressing mental health to prevent shootings. Trump did not offer specific solutions to addressing the mental health problem, but said there are “so many things that can be done.”

 

When candidates do talk about mental health, what they say falls very clearly along party lines. Republican candidates who do address the issue tend to do so in the context of veterans affairs or to recommend institutionalizing certain mentally ill people rather than focusing on gun control. Democratic candidates who bring up mental health tend to do so in the context of reducing the flow in the prison pipeline and addressing substance use disorders. In other words and not surprisingly, mental health gets a mention where it seems to be politically expedient.

 

For more information, you can view each candidate’s political website.

 

References:
Willingham, E. (2015, September 6).What does your 2016 Presidential Candidate Say about Mental Health? Forbes. Retrieved from http://www.forbes.com/sites/emilywillingham/2015/09/06/what-does-your-2016-presidential-candidate-say-about-mental-health/#6ccc3de6884d

 

Witkin, R. (2016, February 24)Where the 2016 Candidates Stand on Mental Health Issues. NBCNews. Retrieved from http://www.nbcnews.com/politics/first-read/where-2016-candidates-stand-mental-health-issues-n524826

 

Jonathan Torres, M.S.
WKPIC Doctoral Intern

 

Posted in Blog, Continuing Education, Current Interns, Friday Factoids, General Information, Mental Health and Wellness, Resources for Interns | Tagged , | Leave a comment

Friday Factoid Catch-up: MDMA-Assisted Psychotherapy for Posttraumatic Stress Disorder

 

A drug often known as “Ecstasy” or “Molly,” has for decades been used as a party drug in clubs and for all-night raves. But lately, ±3, 4-methylenedioxymethamphetamine (MDMD) is also being used in very different settings and for a very different purpose. Pharmacologically, MDMA acts as a serotonin-norepinephrine-dopamine releasing agent and reuptake inhibitor. Basically, MDMA massively increases the release of serotonin, dopamine, and oxytocin. Respectively, these chemicals in the brain help you feel relaxed and calm, help you stay alert, and help you bond with people and be more trusting. Increased feelings of trust and compassion towards others would allow people to process their trauma, which could make an ideal adjunct to psychotherapy for PTSD.

 

The Food and Drug Administration (FDA) has approved phase two clinical studies of the treatment, and they are now underway in four separate locations in South Carolina, Colorado, Canada, and Israel. Results so far have been promising. Preliminary studies have shown that MDMA in conjunction with psychotherapy can help people overcome PTSD and possibly other disorders as well. MDMA is not the same as “Ecstasy” or “Molly.” Substances sold on the street under these names may contain MDMA, but frequently also contain unknown and/or dangerous adulterants. In laboratory studies, pure MDMA has been proven sufficiently safe for human consumption when taken a limited number of times in moderate doses. In MDMA-assisted psychotherapy, MDMA is only administered a few times, unlike most medications for mental illnesses which are often taken daily for years, and sometimes over the course of a lifetime.

 

Recent test results have shown 83 percent of the subjects receiving MDMA-assisted psychotherapy in a pilot study no longer met the criteria for PTSD, and every patient who received a placebo and then went on to receive MDMA-assisted psychotherapy experienced significant and lasting improvements. Long-term follow-up of patients who received MDMA-assisted psychotherapy revealed that overall benefits were maintained an average of 3.8 years later. These results indicate a promising future for MDMA-assisted psychotherapy for PTSD and lay the groundwork for continued research into the safest and most effective ways to administer the treatment.

 

The Multidisciplinary Association for Psychedelic Studies (MAPS) is undertaking a roughly $20 million plan to make MDMA into a FDA approved prescription medicine by 2021, and is currently the only organization in the world funding clinical trials of MDMA-assisted psychotherapy. For-profit pharmaceutical companies are not interested in developing MDMA into a medicine because the patent for MDMA has expired. Data from Phase 2 studies will be used to plan Phase 3of MAPS’ drug development program. MAPS will work with the FDA to agree on a design for Phase 3 studies and submit the findings to the FDA in a New Drug Application (NDA) to approve MDMA-assisted psychotherapy as a prescription treatment for PTSD. Phase 3 of the development program will involve scores of therapists and hundreds of subjects in multiple countries and large multi-center trials. The challenge is no longer convincing regulatory agencies of the value of this research, but finding the financial resources for conducting the Phase 3 studies required to make MDMA-assisted psychotherapy a legally available treatment for those who need it most.

 

References:
Mithoefer, M.C., Wagner, M.T., Mithoefer, A.T., Jerome, L., & Doblin, R. (2011). The safety and efficacy of ±3,4-methylenedioxymethamphetamine-assisted psychotherapy in subjects with chronic, treatment-resistant posttraumatic stress disorder: the first randomized controlled pilot study. Journal of Psychopharmacology, 25(4), 439-452.

 

Mithoefer, M.C., Wagner, M.T., Mithoefer, A.T., Jerome, L., Martin, S.F., Yazar-Klosinski, B.,
Doblin, R. (2012). Durability of improvement in posttraumatic stress disorder symptoms and absence of harmful effects or drug dependency after 3,4-methylenedioxymethamphetamine-assisted psychotherapy: a prospective long-term follow-up study. Journal of Psychopharmacology, 0 (0), 1-12. DOI: 10.1177/0269881112456611

 

Oehen, P., Traber, R., Widmer, V., & Schnyder, U. (2012). A randomized, controlled pilot study of MDMA (±3,4-Methylenedioxymethamphetamine)- assisted psychotherapy for treatment of resistant, chronic Post-Traumatic Stress Disorder (PTSD). Journal of Psychopharmacology, 0, 1-13. DOI: 10.1177/0269881112464827

 

Jonathan Torres, M.S.
WKPIC Doctoral Intern

 

Posted in Blog, Continuing Education, Current Interns, Friday Factoids, Mental Health and Wellness, Resources for Interns | Tagged | Leave a comment

Friday Factoid: U.S. Preventative Services Task Force (USPSTF) Recommends Depression Screening for Older Adolescents

Counseling

National data suggest that up to 8 percent of U.S. adolescents experience an episode of major depression in a given year. Children and adolescents with Major Depressive Disorder (MDD) typically have functional impairments in their performance at school or work, as well as in their interactions with their families and peers. Depression in children and adolescents has been found to be strongly associated with recurrent depression in adulthood and increase the risk for suicidal ideation, suicide attempts, and suicide completion. Among children and adolescents aged 8 to 15 years, 2% of boys and 4% of girls reported having MDD in the past year.

 

In a new guideline, the USPSTF recommended that primary care clinicians should screen adolescents aged 12 to 18 years for MDD. There has been adequate evidence found that screening tests could help detect depressive symptoms and lead to appropriate treatments. Adolescents who are screened and identified in primary care settings as having MDD and then treated have a reduction in symptoms and an improvement in daily functioning. In drafting the guideline, Dr. Siu, chairperson of the USPSTF, identified five studies on the accuracy of screening for MDD in primary care facilities and six studies on the efficacy of treatment. The authors noted there was no direct evidence of harm for screening in a primary care facility and the screenings had “reasonable accuracy” for picking up adolescents with MDD. When treatment is provided, the degree of harm resulting from antidepressant-related adverse events, psychotherapy, and collaborative care appeared to be beneficial and were not associated with significant harm.

 

The USPSTF recommend screening this age group when adequate systems are “in place to ensure accurate diagnosis, effective treatment, and appropriate follow-up.” The recommendation grade of B was given which indicates there is moderate certainty that the net benefit is moderate to substantial.  There are several tools available for screening adolescents. The two most commonly studied are the Patient Health Questionnaire for Adolescents and the primary care version of the Beck Depression Inventory. The USPSTF opted not to issue any recommendation on screening for children aged 11 years and younger because of insufficient evidence. In addition, they note that more research is needed to better assess the effects of screening children on their health outcomes, the effect of comorbidities, the effectiveness of psychotherapy and combined-modality treatments, and the incidence of uncommon adverse events.

 

There are several risk factors that might help identify individuals who are at higher risk for developing symptoms of depression. These factors include, female gender, family (especially maternal) history of depression, prior episode of depression, other mental health or behavioral problems, chronic medical illness, overweight and obesity, and, in some studies, Hispanic race/ethnicity. Other psychosocial risk factors include childhood abuse or neglect, exposure to traumatic events (including natural disasters), loss of a loved one or romantic relationship, family conflict, uncertainty about sexual orientation, low socioeconomic status, and poor academic performance.

 

References:
London, S. (2016, February 9). USPSTF Recommends Depression Screening for Older Adolescents. Medscape. Retrieved from http://www.medscape.com/viewarticle/858653

 

Sui, A.L. (2016). Screening for Depression in Children and Adolescents: U.S. Preventive Services Task Force Recommendation Statement. Annals of Internal Medicine.

 

Jonathan Torres, M.S.
WKPIC Doctoral Intern

Posted in Blog, Continuing Education, Current Interns, Friday Factoids, Mental Health and Wellness, Resources for Interns | Tagged , , | Leave a comment